解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Insulin-like growth factor-binding protein-2 (IGFBP-2) is considered to be a human tumor antigen, and the tumor-specific immunity of IGFBP-2 has been reported in several types of cancer. The purpose of this study was to evaluate whether autoantibodies to IGFBP-2 can be used as diagnostic markers in lung cancer. The re...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1699
更新日期:2013-01-01 00:00:00
abstract::The aim of the present study was to assess whether (-)-epigallocatechin 3-gallate (EGCG) via epigenetic modifications, regulates Raf kinase inhibitor protein (RKIP) expression and invasive metastatic activity in AsPC-1 pancreatic adenocarcinoma cells. Basal levels of RKIP were examined in various human pancreatic canc...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1686
更新日期:2013-01-01 00:00:00
abstract::Although Bmi1 is well established as one of the most commonly activated oncogenes, the precise role of Bmi1 during hepatocarcinogenesis remains unclear. In addition, Bmi1 provides a potential therapeutic target for the future treatment of hepatocellular carcinoma (HCC). In this stud...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1693
更新日期:2013-01-01 00:00:00
abstract::A multi-kinase inhibitor, sorafenib, was recently approved and is currently recommended for the treatment of advanced hepatocellular carcinoma (HCC). However, HCC treatment outcomes are still poor and necessitate improvement. Therefore, we investigated the influence of sorafenib in ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1676
更新日期:2013-01-01 00:00:00
abstract::Adenosine monophosphate-activated protein kinase (AMPK) is a principal intracellular energy sensor which regulates energy producing pathways and energy requiring pathways when the cellular AMP/ATP ratio is altered. BML-275 (compound C), a well-known inhibitor of AMPK, has been found...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1672
更新日期:2012-12-01 00:00:00
abstract::Acute lymphoblastic leukemia (ALL) with translocation t(4;11) is a high-risk leukemia found in 60-85% of infants with ALL and is often refractory to conventional chemotherapeutics after relapse. To evaluate the efficacy of dietary resveratrol in vivo, 5-week-old NOD.CB17-Prkdcscid/J mice were fed a control diet or a d...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1650
更新日期:2012-12-01 00:00:00
abstract::MicroRNAs (miRNAs) are small non-coding, endogenous, single-stranded RNAs. MiRNAs have been implicated in different areas such as the immune response, neural development, DNA repair, apoptosis, oxidative stress response and cancer. However, while the majority of miRNAs are found int...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:10.3892/ijo.2012.1647
更新日期:2012-12-01 00:00:00
abstract::Allyl isothiocyanate (AITC), a member of the isothiocyanate (ITC) family found in a constituent of cruciferous vegetables, possesses anticancer activity and induces apoptosis in various types of human cancer cell lines. However, no available information showed antitumor effects in human breast adenocarcinoma cells. Th...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1640
更新日期:2012-12-01 00:00:00
abstract::Lymph node metastasis of tumors is a crucial early step in the metastatic process. Tumor lymphangiogenesis plays an important role in promoting tumor metastasis to regional lymph nodes. Norcantharidin (NCTD) has been reported to possess potent anti-angiogenesis and antitumor propert...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1603
更新日期:2012-11-01 00:00:00
abstract::Hedgehog (HH) pathway Smoothened (Smo) inhibitors are active against Gorlin syndrome-associated basal cell carcinoma (BCC) and medulloblastoma where Patched (Ptch) mutations occur. We interrogated 705 epithelial cancer cell lines for growth response to the Smo inhibitor cyclopamine ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1599
更新日期:2012-11-01 00:00:00
abstract::The isolation of circulating tumor cells (CTCs) from the blood of patients afflicted with solid malignant tumors becomes increasingly important as it may serve as a 'liquid biopsy' with the potential of monitoring the course of the cancer disease and its response to cancer therapy, with subsequent molecular characteri...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1557
更新日期:2012-10-01 00:00:00
abstract::Cytokine expression in a tumor microenvironment can impact both host defense against the tumor and tumor cell survival. In this study, we sought to clarify whether the cytokine gene expression profile could have clinical associations with ovarian cancer. We analyzed the expression of 16 cytokine genes (IL-1α, IL-1β, I...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1533
更新日期:2012-09-01 00:00:00
abstract::Oral squamous cell carcinoma (OSCC) is the sixth most common cancer and frequently metastasizes to the cervical lymph nodes, leading to poor survival of patients with OSCC. However, the mechanism of lymph node metastasis is not fully understood. To clarify the molecular mechanism un...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1529
更新日期:2012-09-01 00:00:00
abstract::We previously discovered the coexistence of dormant and proliferating cancer stem cells (CSCs) in gastrointestinal cancer, which leads to chemoradiation resistance. CD13-/CD90+ proliferating liver CSCs are sensitive to chemotherapy, and CD13+/CD90- dormant CSCs have a limited prolif...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1531
更新日期:2012-09-01 00:00:00
abstract::We previously showed that the B cell leukemia cell line NALM-6 had the highest susceptibility among a number of leukemia cell lines to spiruchostatin B (SP-B), a potent histone deacetylase (HDAC) inhibitor. We also showed that SP-B-induced cytotoxicity depended on induction of apopt...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1507
更新日期:2012-09-01 00:00:00
abstract::The deregulation of the epidermal growth factor receptor (EGFR) pathway plays a major role in the pathogenesis of prostate cancer (PCa). However, therapies targeting EGFR have demonstrated limited effectiveness in PCa. A potential mechanism to overcome EGFR blockade in cancer cells is the autocrine activation of alter...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1509
更新日期:2012-09-01 00:00:00
abstract::Overexpression of TMPRSS4, a cell surface-associated transmembrane serine protease, has been reported in pancreatic, colorectal and thyroid cancers, and has been implicated in tumor cell migration and metastasis. Few reports have investigated both TMPRSS4 gene expression levels and ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1513
更新日期:2012-09-01 00:00:00
abstract::Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is promising for cancer treatment owing to its selective cytotoxicity against malignant cells. However, some cancer cell types, including malignant melanoma cells, are resistant to TRAIL-induced apoptosis. Therefore, dr...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1483
更新日期:2012-08-01 00:00:00
abstract::Breast cancer is the neoplasia with the highest incidence in women worldwide. Proteomics approaches have accelerated the discovery of diagnostic and prognostic biomarkers. Here, we compared the proteomic profiles of breast tumors versus non-tumoral tissues in order to identify modul...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1478
更新日期:2012-08-01 00:00:00
abstract::Orlistat is an orally administered anti-obesity drug that has shown significant antitumor activity in a variety of tumor cells. To identify the proteins involved in its antitumor activity, we employed a proteomic approach to reveal protein expression changes in the human ovarian can...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1465
更新日期:2012-08-01 00:00:00
abstract::Chronic lymphocytic leukemia (CLL) is a low-grade lymphoid malignancy incurable with conventional modalities of chemotherapy. We aimed to examine the proapoptotic effects of a novel proteasome inhibitor, N,N'-di-(m-methylphenyi)-3,6- dimethyl-1,4-dihydro-1,2,4,5-tetrazine-1,4-dicarboamide (ZGDH...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1467
更新日期:2012-08-01 00:00:00
abstract::Docetaxel is one of the most commonly used chemotherapeutic agents in breast cancer. To avert from significant toxicities with no clinical benefit, identification of predictive markers for response is one of the most important unsolved clinical needs. Therefore, the potential associ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1470
更新日期:2012-08-01 00:00:00
abstract::Irvalec® (elisidepsin trifluoroacetate, PM02734) is a novel marine-derived cyclic peptide belonging to the Kahaladide family of compounds, currently in clinical trials with preliminary evidence of antitumor activity. Previous studies have shown a correlation between elisidepsin sens...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1425
更新日期:2012-07-01 00:00:00
abstract::The epithelial-to-mesenchymal transition (EMT) confers an aggressive subtype associated with chemotherapy resistance in epithelial cancers. However, the mechanisms underlying the EMT and its associated signaling dysfunctions are still poorly understood. In two genetic models of MCF-...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1457
更新日期:2012-07-01 00:00:00
abstract::Pemetrexed (PEM) is a novel, multitargeted, antifolate, antineoplastic agent for the treatment of non-small cell lung cancer and malignant pleural mesothelioma. Additional effects of nitric oxide (NO) donors on the chemosensitivity of cancers have been reported. However, the effects of an NO donor on PEM-induced cytot...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1461
更新日期:2012-07-01 00:00:00
abstract::Colorectal cancer (CRC) is one of the most common cancers; however, the development of drugs to treat the condition has reached a plateau. Bortezomib (PS-341, Velcade®) is a proteasome inhibitor approved for the treatment of hematological malignancies, including multiple myeloma. A few trials of bortezomib, alone or i...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1448
更新日期:2012-07-01 00:00:00
abstract::Hsp90α is a molecular chaperone protein involved in the structural maturation of oncogenic signaling proteins. Hsp90 was recently identified as an anticancer target; various studies are ongoing to find ways for managing cancer through Hsp90α. However, this approach is limited by reported side-effects. Hypoxia is a hal...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1450
更新日期:2012-07-01 00:00:00
abstract::Cytochrome P450 1A1 (CYP1A1) is a member of the cytochrome p450 enzyme family, which is involved in the metabolisms of carcinogenic metabolites, such as benzo(a)pyrene. In this study, we identified miR-892a as a negative regulator of CYP1A1 expression. Luciferase assays revealed a s...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1418
更新日期:2012-07-01 00:00:00
abstract::An altered expression of microRNAs (miRNAs) contributes both to the development of cancer and to the progression of the disease. Malignant tumours and tumour cell lines have widespread deregulated expressions of miRNAs compared to normal tissues. In this study, we investigated the expression profiles of 340 mammalian ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1420
更新日期:2012-07-01 00:00:00
abstract::The objective of these studies was to examine the murine pharmacokinetics, pharmacodynamics and metabolism of (3-(1H-indol-2-yl)phenyl)(1H-indol-2-yl)methanone (Indole 15), a novel tubulin inhibitor for the treatment of cancer. We developed HPLC and LC/MS/MS assays to quantitate Indole 15 and characterize its metaboli...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1442
更新日期:2012-07-01 00:00:00
abstract::Recent studies have demonstrated that natural antisense transcripts, which are complementary sequences to messenger RNA, have important cellular functions such as the stabilization and silencing of mRNA. However, the possible contribution of antisense transcripts in hepatocellular c...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1382
更新日期:2012-06-01 00:00:00
abstract::Fatty acid synthase (FASN) is a key enzyme that plays a critical role in numerous metabolic functions by catalyzing the synthesis for long-chain fatty acids. FASN is highly expressed in various human cancers. This preferential expression makes FASN an attractive target for anticance...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1401
更新日期:2012-06-01 00:00:00
abstract::There is emerging evidence for the prognostic role of various microRNA (miRNA) molecules in colon cancer. The aim of this study was therefore to compare the miRNA profiles in the primary tumor of patients with recurrent and non-recurrent colon cancer. The study population included 110 patients, 51 (46%) with stage I a...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1403
更新日期:2012-06-01 00:00:00
abstract::Collagen type I is an abundant component of the extracellular matrix and due to its longevity, constitutes a prominent target of non-enzymatic post-translational in vivo modifications such as carbamylation and glycation. These protein modifications involved in aging, renal diseases and diabetes, are linked to elevated...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1393
更新日期:2012-06-01 00:00:00
abstract::This study aimed to analyze expression of Müllerian inhibiting substance type II receptor (MISRII) protein and mRNA in cervical neoplasia, to demonstrate the growth inhibition of cervical cancer cells by administration of highly purified recombinant human Müllerian inhibiting substa...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1370
更新日期:2012-06-01 00:00:00
abstract::Cordycepin (3'-deoxyadenosine), a major bioactive compound of Cordyceps militaris, has many pharmacological actions, such as anti-inflammatory and anticancer activities. In this study, the relationship between inhibition of cell motility and anti-invasive activity by cordycepin in L...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1332
更新日期:2012-05-01 00:00:00
abstract::The tumour suppressor gene hypermethylated in cancer 1 (HIC1) is a transcriptional repressor, which functionally cooperates with p53. Loss of HIC1 function is associated with the development of various tumor entities. The aim of this study was to elucidate the relevance of CpG islan...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1367
更新日期:2012-05-01 00:00:00
abstract::The MUC1 heterodimeric protein is aberrantly overexpressed in diverse human carcinomas and contributes to the malignant phenotype. The MUC1-C transmembrane subunit contains a CQC motif in the cytoplasmic domain that has been implicated in the formation of dimers and in its oncogenic function. The present study demonst...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1308
更新日期:2012-05-01 00:00:00
abstract::Recently, the inflammatory cytokine IL-6 has been reported as a potent inducer of epithelial-mesenchymal transition (EMT) in breast cancer cells with an epithelial phenotype. Furthermore, EMT induces stem cell features in normal and transformed mammary cells. We explored whether IL-...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1275
更新日期:2012-04-01 00:00:00
abstract::It has been demonstrated that triptolide inhibits the growth of several types of cancer cells in vitro and prevents tumor growth in vivo by inducing apoptosis and autophagy. Here we showed that Tripchlorolide (T4) significantly suppressed the proliferation of A549 cells in a dose- a...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1278
更新日期:2012-04-01 00:00:00